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Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus

Moreover, antioxidants quercetin (QE), baicalein (BE) and myricetin (ME) effectively downregulated ROS and MMP9 and inhibited glioma cell invasion/migration events in vitro ( However, some studies have shown that intake of antioxidants, such as carotenoids (371), vitamin E (372), and coffee (373), is not associated with the risk of developing gliomas

Here we evaluate the TME mechanisms that trigger oxidative stress along with their consequences on cancer treatment through antioxidant interventions

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doi: 10.1016/j.ymthe.2017.03.011

49 The gene for 5-methylthioadenosine phosphorylase (MTAP), a key enzyme of the methionine salvage pathway, is frequently deleted in human cancers