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Cell control experiments and analyses demonstrate that glycyrrhizic acid, a known HMGB1 binder, which reduces HMGB1 expression induced by TMAO, can be used to treat the disruption of cell junction proteins (Singh et al., 2019)

Accessed June 5, 2020

Across included trials, ALC was well tolerated, with adverse events primarily mild and limited to gastrointestinal or central nervous system complaints

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Symptoms can include difficulty breathing, hives, and swelling of the face, lips, tongue, or throat [12]

Acidic extracts used mobile phases of (A) 0.1% formic acid in water and (B) 0.1% formic acid in methanol, with a gradient from 0% B to 70% B over 4 min, 7098% B over 0.5 min, followed by 0.9 min at 98% B