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Once the nanoparticles were internalized, ferric ions released from the bone structure were able to trigger the Fenton reaction to produce ROS, which resulted in a significant accumulation of LPO

While brain interstitial fluid tau concentrations are reported to be nearly twice as high during the active period of the rest-activity cycle in humans [8], it is noteworthy that, to the best of our knowledge, no study has investigated whether the deletion of core clock genes, simulating circadian disruption, leads to an increase in tau hyperphosphorylation

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In contrast, AA or AG carriers had a decreased risk of grade 1-4 lymphopenia as observed in 94 NSCLC patients (OR = 0.323

Schushan et al., 2012) (Figure 2)

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