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Vitamin E reduces the negative effect of corticosterone, vitamin C is vital for various biosynthesis(collagen, 1,25 dihydroxy vitamin D and adrenaline) and regulation of diverse reaction(secretion of corticosterone, regulation of body temperature and activation of the immune system)

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The diagnosis of PSC currently relies on 1) characteristic cholangiographic abnormalities of the biliary tree

Hence, it is evident that gene therapy holds the promise to address DMED and diminish patient reliance on PDE5 inhibitors