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Uptake of L-glutamine uptake is markedly increased in patients with SCD, primarily to increase the total intracellular NAD level ( In the future it could be a useful combination therapy with HU ( As the endothelium emerge as a key factor in the constant activation of adhesion molecules in sickle RBCs, these adhesion molecules present a very attractive therapeutic target

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2 Trowbridge M, Jr., Wadsworth RC, Moffitt E

Crit Rev Food Sci Nutr 64:70677084