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CB2R is expressed in monocytes and CB1R mRNA transcripts are modestly present (73)

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110,111 Through a series of complex disruptions of the genome, cells acquire the accumulation of deleterious alterations irreversibly to survive in purifying selection (removing deleterious genetic variations) of human germline evolution, further obtaining fitness, attenuating tumor cell attrition and evolving to malignancies

Moreover, future research plans include employing conditional knockout mouse models to more comprehensively and deeply assess the neuroprotective effects mediated by SIRT1