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95% CI 0.08-2.84, total of 17,324 patients, figure 4)

Clinical evidence demonstrates that GLP-1 receptor agonists (GLP-1RAs) confer dual benefits in DM-COPD comorbidity: reducing asthma exacerbation risk (Foer et al., 2023), while ameliorating bronchial hyperresponsiveness via PKA activation in airway epithelial cells (Rogliani et al., 2016)