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[DOI] [PMC free article] [PubMed] [Google Scholar] 171.de Jong C., Stolwijk T., Kuppens E., de Keizer R., van Best J

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The Early Detection Initiative (EDI) (NCT03731637, NCT04662879) is a randomized controlled trial where patients between 50 and 85 years of age with the presence of hyperglycemia and/or diabetes within 90 days will be randomized into an observation arm and an intervention arm

These findings are clinically significant as ligand-independent nuclear translocation of AR and GR promotes resistance to ADT in the treatment of prostate cancer, currently a major clinical problem

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