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Survodutide's GLP-1 agonism would confound results by enhancing beta-cell insulin secretion in response to glucose, making it unsuitable for studies where incretin effects must be excluded

For example, in pediatric medication, due to the differences in weight and body surface area between children and adults, it is necessary to accurately calculate drug dosage based on age and weight

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Since theyre more potent in effect, their use may be prohibited outright for some patients scheduled for an epidural steroid injection, since the side effects of the shot itself can trigger some serious complications if the patient isnt prepared