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The enhancement of viral infectivity could be attributed to the hypomethylation of STAT1, leading to a reduced binding of STAT1 to the interferon-stimulated response element and thus reduction of the expression of interferon-stimulated genes (ISGs), weakening the antiviral effects of interferon (78, 79)

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doi:10.1161/01.cir.0000018653.19696.01

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