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Eltzschig and Carmeliet, 2011

But youve gotta give it time to build up enough B12 reserves first

Increased production of ROS increases oxidative stress and therefore promotes apoptosis via multiple caspase pathways in PTECs upon exposure to high glucose (89, 90)

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doi: 10.1111/j.1365-2826.1993.tb00535.x 2 GurunathanSKangM-HSongHKimNHKimJH

87 These findings clearly indicate that the stimulation of increases in eNOS expression without simultaneously increasing vascular levels of BH 4 may lead to eNOS uncoupling because of the stoichiometric relationship between endothelial BH 4 and NOS activity