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However, their clinical applications face several significant challenges

The fact that BPC 157 can inhibit the mRNA expression of inflammatory mediators (iNOS, IL-6, IFN, and TNF-) as well as increase protein expression of HSP70, HSP90 and promote the expression of antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2 and GST-pi [37] indicate that this peptide interacts with several molecular pathways [5,25,29,31,32,33,34,35,36,37]

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In comparison, colon crypts from the D3-Veh group were unable to self-expand, displayed less budding, and greater cell death and degradation, whereas crypts from IPA-treated colitic mice had superior budding and organoids forming ability (Fig