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Lipid peroxidation of polyunsaturated fatty acids, particularly in cellular membranes, represents a hallmark event of ferroptosis, while GPX4 and the system the cystine/glutamate antiporter (Xc/) GSH axis serve as central antioxidant defenses that counteract this process (24-28)

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Afterwards, desensitisation is performed in these cases if there are no suitable alternative drugs

However, logistics and high costs remain significant barriers to the widespread application of these approaches, and there are currently no established interventions in the recipient that can reduce the incidence of DGF