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Pratic D, Uryu K, Leight S, Trojanoswki JQ, Lee VM

There are various potential causes of vitamin B12 deficiency besides pernicious anemia, which gastrointestinal surgery long-term use of certain medications, such as proton pump inhibitors genetic intrinsic factor defects dietary deficiency Pernicious anemia requires lifelong treatment

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It is produced naturally in the body as an assembly of 3 amino acids glycine, cysteine and glutamine

Research has demonstrated that heightened levels of TMAO are correlated with a heightened likelihood of kidney disease advancement and cardiovascular incidents among individuals with chronic kidney disease

For instance, circ-cIARS binds to ALKBH5, an RNA-binding protein that negatively regulates ferritinophagy and ferroptosis, thereby blocking its activity (Ou et al., 2022)