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The release of proteases, including matrix metalloproteinases (MMPs), tissue proteases and neutrophil elastase, degrades the extracellular matrix and alveolar elastin, leading to localized and generalized alveolar emphysema (25)

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Broome, U., Scheynius, A

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Some common examples of heavy metal pollution include, but are not limited to: fish consumption, mercury amalgam dental fillings, mercury preservatives in vaccines, cigarettes, auto exhaust, newspapers, canned and frozen foods, aluminum cookware, insecticides, fungicides and pesticides, water pipes, cosmetics and hair dyes, antacids, and deodorants

In a case-control study, supplementation with 20,000 IU vitamin D 2 per day for six weeks resulted in decreased symptoms and improved quality of life in participants with chronic urticaria and vitamin D insufficiency who were also being treated with antihistamines (Boonpiyathad 2014)