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Co-trimoxazole is a US Food and Drug Administration-approved drug consisting of two antifolates, trimethoprim and sulfamethoxazole, which are on the list of the World Health Organization essential medicines that have been used as effective antimicrobial agents for over 40 years [34, 70]

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After the use of IL-17 inhibitors the immunohistochemical staining also showed moderate intensity staining of inflammatory cells in the lamina propria, but the glandular epithelium of the crypts was widely expressed

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