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C4 cleavage is a key step of the classical/lectin pathways activation, generating two fragments: the larger C4b fragment that covalently binds to the target cell surface, and the smaller peptide C4a that is released (Fig

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(The terminology is evolving internationally, with some guidelines now using metabolic dysfunction-associated steatotic liver disease [MASLD], though NAFLD remains the term in current UK guidance.) According to NICE guideline NG49 , NAFLD affects approximately 2030% of the UK population and is strongly associated with metabolic syndrome

10.1142/S0192415X18500362 Am J Chin Med