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Penetration Mechanisms and Efficiency Nanocarriers deliver active ingredients through the skin barrier in three main ways: The transappendageal pathway lets nanocarriers move through hair follicles and sebaceous glands [2]

10.1007/s12195-018-00557-w 173 WardN

Conversely, the skeletal muscle-myokine axis supports recovery: exercise-responsive irisin enhances brain-derived neurotrophic factor expression to promote axonal regeneration, with post-stroke depletion worsening motor outcomes [59]

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One of the disadvantages of in-vitro studies is that the effective dose used is much higher than concentration that can be achieved in humans

doi:10.1016/j.bpc.2016.12.004 Ratan ZA, Haidere MF, Hong YH, et al