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At the molecular level in rodent models, exercise entrains the core clock by shifting expression patterns of Per2 (Kemler et al., 2020), and can prevent oxidative damage derived from melatonin deficit or circadian disruption (Jana et al., 2020

Subsequently, M2 phenotype is polarized from macrophages and primarily responsible for tissue repair and anti-inflammatory pathways via producing mediators such as IL-10 and TGF- [29]

PMID: 29440447

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In various, embodiments, Ra, Rb, and Rc are each independently hydrogen, C1-6alkyl, C2-6alkenyl, or C3-6cycloalkyl