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Autophagy has become an evolutionarily conserved process extended to every eukaryotic species

It also explains why combination and stacking strategies are sometimes used

Front Neurol 10:710 Bachoud-Lvi AC, Ferreira J, Massart R, Youssov K, Rosser A, Busse M, Craufurd D, Reilmann R, De Michele G, Rae D, Squitieri F, Seppi K, Perrine C, Scherer-Gagou C, Audrey O, Verny C, Burgunder JM (2019b) International guidelines for the treatment of Huntingtons disease

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Bariatric surgery remains one of the most effective interventions for severe obesity, yet some patients experience inadequate weight loss or weight regain years after their procedure

Thus, as used herein, stochastic mutagenesis is manifested in processes such as error- prone PCR and stochastic shuffling, where the mutation(s) achieved are random or not predetermined