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10.1186/gb-2012-13-9-r79 72 MukhopadhyaI.HansenR.El-OmarE

Antioxid Redox Signal (2008) 10(2):179206

Early phase reflecting nicotinic stimulation (CNS, Parasympathetic & Sympathetic) (first 15 mins to an hour): nausea & vomiting a result of parasympathetic stimulation of the GI tract, causing increased tone and motility, resulting in nausea, vomiting, diarrhea, and voiding of urine (Vanderah & Pappano, 2021)

In order to overcome these limitations, researchers have integrated multidisciplinary strategies and developed various innovative DDS to achieve efficient, accurate and controllable delivery and release of PROTAC