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Some patients tolerate gradual adjustments better than aggressive protocols

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doi: 10.1038/s41419-017-0135-z 10 KangQYangC

Biomarker validation An additional challenge with the translation of therapeutic targets identified in genetic screens resides, in some capacity, in the heterogeneity present even within the genomic landscape of a specific tumor type

By using LAT1-4F2hc as the model, we found that the LAAM GSH-CQDs could bind to the LAT1 mainly through hydrogen bonds formed between the amino acid groups on LAAM GSH-CQDs and the Glu457, Glu78, Asn242 and Leu238 residues in LAT1 with a docking energy of 8.80 kcal mol 1 (Supplementary Fig