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Therapeutic targeting of tumor-derived R-spondin attenuates -catenin signaling and tumorigenesis in multiple cancer types

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Functional enrichment analysis showed that MOTS-c improved angiogenesis, inflammation and apoptosis in terms of cell function, suggesting that MOTS-c may have the same effect as aerobic exercise and improve heart failure in patients with diabetes through NRG1-ErbB4 pathway (14)