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While mitochondria have their own antioxidant defenses, including mitochondrial SOD, these defenses are often insufficient to neutralize the high levels of ROS produced during oxidative phosphorylation, especially if mitochondrial function is compromised

Although the findings were promising, the studys credibility is tempered by its small sample size (n = 10), short duration of treatment, and the absence of detailed dietary intake data during the trial period [112]

It uses NADPH still, though

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Activation of the hypothalamic-pituitary-adrenal axis and lymphocyte responsiveness