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However, in diabetes, these defence mechanisms are compromised due to chronic inflammation, contributing to the progression of damage and the disease itself

C57BL/6 mice were administered 4 mg of metformin twice daily (equivalent to our human experimental dose of 1000 mg twice daily) (Nair and Jacob, 2016), starting from 3 days before vaccination until either D3 (7-day course) or D10 (extended course) after vaccination, and serum was collected at D21 post-vaccination for antibody measurement (Fig

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107 In contrast to this finding, mice expressing both the IL-5 and eotaxin2 transgenes harbor increased activated eosinophils in the lung and exhibit reduced barrier function