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However, compound 17 exhibited high liver microsome clearance

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Quantification of the HSF-1::GFP foci showed fewer foci in the ctl-2(ua90)II worms compared with WT (Fig 1F and G), suggesting altered regulation of the HSR in the peroxisomal mutant

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HD is caused due to expansion of the polyglutamine tract in the protein Huntingtin resulting in aggregates

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