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Furthermore, Clostridium scindens upregulates monoamine oxidase A (MAO-A) activity, promoting the oxidative deamination of serotonin into the inactive metabolite 5-hydroxyindoleacetic acid (5-HIAA) (Li et al., 2025)

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It also enhanced the bodys adaptive immune response, leading to increased proliferation of tumor-specific T cells and the activity of CD8 + T cells, as well as inhibiting angiogenesis