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In one study, the cells depleted of mitochondria could still undergo ferroptosis [14], while in another study authors described significantly attenuated ferroptosis [3]

438 Even in the presence of normal blood glucose, insulin resistance is still harmful, and the lack of insulin receptor signaling pathways in renal pedal cells induces a disease state similar to diabetic nephropathy

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The peripheral IGF-1/IGF-1R pathway may play a role in promoting pain, while the central (spinal cord) IGF-1/IGF-1R pathway may play a role in inhibiting pain