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New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters

Only under competent medical care should this course of action be taken

The same vector was used to create the recombinant strains

J Biol Chem 287 , 44034410, doi: 10.1074/jbc.R111.283432 (2011)

A common DIO2 haplotype composed of the minor C-allele of SNP rs225014 and the common C-allele of SNP rs12885300 was significantly associated with advanced hip OA, as indicated by a higher odds ratio 101,102,103

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