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Astroglial P2Y 1 and P2X 7 receptors are key mediators in epilepsy and MS

and Schroder K., NLRP3 Inflammasome Activation: The Convergence of Multiple Signalling Pathways on ROS Production?, Nature Reviews Immunology 10, no

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the latter are subjected to study in animal models for the elucidation of mechanisms leading to development and progression

Since the current definition of ferroptosis is a cell death process involving lipid peroxidation that is suppressed by both iron chelators and lipophilic antioxidants, any lethal iron-dependent lipid peroxidation would be classified as ferroptosis

This is the level of safety data appropriate for early preclinical research, not for human use