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RSC Adv 5(35):2754027557 Bazan-Socha S, Buregwa-Czuma S, Jakiela B, Zareba L, Zawlik I, Myszka A, Soja J, Okon K, Zarychta J, Kozlik P, Dziedzina S, Padjas A, Wojcik K, Kepski M, Bazan JG (2021) Reticular basement membrane thickness is associated with growth-and fibrosis-promoting airway transcriptome profile-study in asthma patients

This project allows the interrogation of mechanisms in both murine models and human tissue

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Thus, we tested here whether increased VEGFA expression specifically in the RPE (and not in the retina or circulation) is sufficient to induce RPE barrier breakdown and neovascular AMDlike pathologies, by generating mice that overexpress VEGFA only in the RPE postnatally (Vmd2Cre +/WT /ROSASTOP fl/fl VEGFA 164 mice)