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In postischemia brains, oxidative stress directs the activation of astrocytes and microglia which brings striking elevation in the inflammatory mediators such as matrix metalloproteases, chemokines, and cytokines and results in the loss of endothelial cell integrity in the brain by upregulating the neutrophil infiltration and cell adhesion molecules

Under normal conditions, air contains about 21% oxygen, but during HBOT, the pressure inside the chamber is increased to 1.5 to 3 times the normal atmospheric pressure

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