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In the study, we utilized four distinct tau transgenic mouse models including an aggressive, early age onset tauopathy (rTg(tauP301L)4510)Mapt0/0

doi:10.1097/yco.0000000000000527 Nel C, Augustyn L, Bartman N, et al

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The method of claim 1 , wherein said at least one symptom is selected from the group consisting of: impaired or abnormal gait, neuronal oxidative stress, dementia, tremor, impaired balance, weakness, and personality changes

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