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Late-onset nodules refer to the development of lumps or bumps at the site of dermal filler injection that appear after a significant delay, typically weeks to years following the procedure

Furthermore, it has been seen that in many cases in these specific animals and under certain conditions, their endogenous production may not be sufficient and they are often supplemented as a matter of protocol to avoid problems and optimize levels

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The common injection sites include under the skin of the abdomen, thigh, and upper arm

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