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Figures 1 and 2 created in Author contributions DL: Conceptualization, Writingoriginal draft, Writingreview & editing, Visualization

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VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha

Compounds were administered via drinking water (see Methods section), in line with oral administration protocols previously used in adult mice and humans 79,80,81,82

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Lewy-body inclusions Abnormal aggregates of protein that develop inside nerve cells contributing to disorders including Parkinson disease