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Autoimmune diseases tend to have long, asymptomatic prodromal periods and the initiating events leading to loss of self tolerance occur long before the disease becomes clinically manifest.(7) Autoimmunity in general, takes place in several stages: The first stage is called silent autoimmunity and is characterized by the onset of loss of immune self-tolerance without any loss of self-tissue

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Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders

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For instance, GSH can be depleted, through inhibition of its synthesis using an inhibitor of GCL (buthionine sulfoximine, BSO) (57) under conditions that maintain the intracellular cysteine pool intact,