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Changes in nociceptive processing were associated with reduced sucrose-evoked grooming behavior without altering acute nesting behavior, and in spinal cord dysregulated free radical generation as measured by DCF fluorescence intensity, altered immunohistochemical expression of the gliotic markers, Iba-1 and GFAP, and increased permeability of the blood-brain barrier to the small molecule fluorescent tracer, sodium fluorescein, in a time-dependent manner

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To determine whether STR-derived CAR T cells treated with rapamycin had better anti-tumor efficacy in vivo compared to untreated CAR T cells, we inoculated NSG mice with Nalm6 leukemia cells and treated mice with CAR T cells (rapamycin) five days later (Fig

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