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A systematic analysis reveals heterogeneous changes in the endocytic activities of cancer cells

Accumulating evidence establishes asparagine synthetase (ASNS) as a critical driver of malignant progression in solid tumors including prostate cancer, where it sustains tumorigenesis through dual metabolic reprogramming ( In PCa, glutamine serves as a critical upstream hub in ammonium metabolism, with tumors exhibiting profound metabolic rewiring to sustain proliferative and stress-adaptive demands

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