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2.2 Mechanism of MM pathogenesis The pathogenesis of MM is a complex process leading to the replication of a malignant plasma cell clone that originates from the lymphoid B-cell lineage and develops after lineage commitment in the bone marrow ( Multiple mechanisms for MM cell dysregulation have been described, such as translocations of the Cyclin D1 gene with the IgH gene, specific Cyclin D gene amplifications, trisomies, and other cytogenetic events ( Dysregulation of cyclin D appears to be a necessary occurrence in the establishment of abnormal plasma cells

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