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This is a self protective mechanism against TNF- induced oxidative stress

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Histamine also upregulates NE

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This emanates from the fact that synthetic drugs are designed for just a purpose (for instance, treatment of a particular disease) and targeting a certain pathway and mechanism, while a large number of studies have revealed that naturally-occuring compounds are capable of affecting a wide variety of molecular signaling pathways (Guo et al., 2019

Curcumin loaded exosomes (Exo-CUR) was administered orally to nude mice containing the cervical Ca Ski-tumor xenograft to assess its in vivo anti-cancer efficacy