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3.2 Serine metabolism and the immunosuppressive microenvironment The immunosuppressive tumor microenvironment (TME) enables immune evasion, with serine metabolism emerging as a key modulator via metabolite allocation, immune cell regulation, and redox control

Octamer-binding transcription factor 4 (Oct4), also known as the POU domain, class 5, transcription factor 1 (POU51), is a well-known TF extensively associated with maintaining ESC pluripotency and somatic cell reprogramming

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Available at: www.accessdata.fda.gov/cdrh_docs/pdf5/P050034c.pdf

Berger G, Grauwet K, Zhang H et al (2018) Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models