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doi: 10.3390/nu13010028 106 KasarelloK.Cudnoch-JedrzejewskaA.CzarzastaK

While little is known about the metabolic fate of cyclopropyl lipids in humans, cyclopropyl fatty acids are robustly detected in human serum, and may interact directly with the human NR, HNF4, a master regulator of mammalian liver metabolism and homolog of NHR-13, -49, and -80 85,86

Role of the peroxisome proliferator-activated receptor alpha in responses to diisononyl phthalate

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However, when iron is excessively released from ferritinophagy, after overexpression of NCOA4, a cytosolic pathway is created, readying the interaction between NCOA4 and HERC2 for ubiquitination and degradation of ferritin into lysosomes [16,17,18] (Figure 2)