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Additionally, it may reflect the positive and negative alterations in the brain neurotransmitters

These symptoms vary from one individual to another, though, and may affect the following: Skin Clinical symptoms include rashes, acne breakouts, or general skin inflammation

doi: 10.1038/nature05859 77 YangWSSriRamaratnamRWelschMEShimadaKSkoutaRViswanathanVSet al

Pathophysiology of HT-1 In 1977, fumarylacetoacetate hydrolase (FAH) was identified as the deficient enzyme responsible for HT-1 (Figure 1)

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Peer review information Nature Communications thanks Andreas Faissner, Laurent Groc and the other, anonymous, reviewer(s) for their contribution to the peer review of this work