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Transcriptomics has progressed from microarray technology to high-throughput measurement methods, with RNA-seq serving as a leading method owing to its ability to provide comprehensive and precise gene expression data (Osborne et al., 2012)

The NLRP3 inflammasome and subsequent caspase-1 activation cause pyroptosis in macrophages after uptake of oxLDL and might contribute to the progression of atheroma (161, 162)