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This insensitivity appears to result from specific bacteria, such as Lachnospiraceae and mucin-degrading bacteria (e.g., A

In preclinical research, it has been observed to influence local anabolic signaling following mechanical stress

[] A phase 3 double-blind, placebo and randomized controlled clinical trial, which studied the long-term effect of OCA in PBC patients, who did not tolerate or respond to UDCA therapy, revealed that OCA improved liver fibrosis and biliary injury in PBC patients after three years of treatment

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Among these, the relative concentrations of 62 metabolites were significantly influenced by either GDH2 or GDH3 gene deletions (Fig

Ferroptosis, driven by iron-dependent lethal lipid peroxidation, can be inhibited through direct blockade of lipid peroxidation or iron depletion via pharmacological or genetic approaches [21]