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Biological and clinical implications of the MTHFR C677T polymorphism

n = 4 biological replicates

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In k , the box plots show the median (centre) and the 25th and 75th percentiles (bounds of box), and the whiskers indicate the minimum and maximum values

Many patients transition to a maintenance schedule of one shot every 2 to 4 weeks rather than stopping completely

The most interesting NaOCl-sensitive thiol-switches are the enzymes involved in energy metabolism, mycolic acid and fatty acid biosynthesis as well as the various Zn-containing alcohol dehydrogenases, ribosomal proteins and redox-sensing regulators, such as RseA, RshA, Zur and NrdR