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Disruption of this balance has associated with the development of certain inflammatory diseases

doi: 10.2147/cmr.s5598 169 ZhangLWangH

Another mitokine, FGF21, alleviates brain cells apoptosis and improves hippocampal synaptic plasticity as well as dendritic spine density in obese-insulin resistant rats, thus providing neuroprotection and preventing cognitive deterioration [10]

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Kynurenic acid: A metabolite with multiple actions and multiple targets in brain and periphery

This may potentially be because the cell death occurring in BT12 cells in response to cisplatin is ROS-dependent whereas this may not totally be the case in BT16 cells, due to the demonstrated higher expression levels of cytoprotective components of the antioxidant system, GSH and Nrf2