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Treatment side-effects include elevated aminotransferase levels and injection site reactions (lipohypertrophy)

Next, membranes were blocked with 5% BSA in Tris-buffered saline containing 0.1% (v/v) Tween 20 (TBST) for 1 h at room temperature and probed with primary antibodies against corresponding antigens overnight at 4 C

doi: 10.1016/j.intimp.2020.107272 145 SimpsonMFrisbeeAKumarPSchwanCAktoriesKPetriWA

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Of note, the exaggerated levels of pro-inflammatory mediators and the suppressed AKT level are considered the key contributors in disrupting BDNF signaling, which lead to consequent enhancement in neuronal apoptosis and impairment in memory functions (Rossi et al