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Redox Biol 2019;24:101223.ArticlePubMedPMC 7

Oxidative modifications may impair the expression or activity of sarcoplasmic reticulum Ca 2 -ATPase (SERCA2a), leading to defective Ca 2 reuptake during diastole, sustained cytosolic Ca 2 elevation further causes diastolic dysfunction and delayed relaxation [44]

However, the reduced IGFBP binding comes with a significant pharmacokinetic trade-off: IGF-1 DES has an extremely short plasma half-life of only 20-30 minutes compared to the 12-15 hour half-life of endogenous IGF-1 in its IGFBP-bound state

This ensures proper guidance, monitoring for adverse effects, and avoidance of potentially harmful drug interactions, thereby optimizing the safety and efficacy of any integrative approach involving curcumin