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Quercetin pretreatment significantly inhibits LPS-induced apoptosis and inflammation to alleviate RTEC injury, including brush border loss, vacuolization, inflammatory cell infiltration, and necrosis by upregulating SIRT1 expression, inhibiting the NF-B activity and reducing the expression of related pro-inflammatory factors (the level of IL-6, IL-1 and TNF-) and pro-apoptotic protein (cleaved caspase-3, Bax and cleaved caspase-9) (Lu et al., 2021)

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Together, these findings suggest that microbiome shifts associated with trauma exposure and geography may influence PTSD risk by modulating brain structure and neuroinflammatory signaling

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